Guarani missed a chance to move in to second in the Paraguay Division Profesional after a 4-2 home defeat to Rubio Nu on Wednesday.
Jorge Ortega netted a brace for the visitors and goals from Pablo Esteban and Hugo Luzardi lifted Rubio Nu to ninth.
A Juan Ferreyra hat-trick was enough for Olimpia to dispose of Deportivo Carapegua who extended their horror run to four straight defeats.
In matches on Tuesday, Libertad jumped to second after an 87th minute Sergio Aquino penalty broke the hearts of Sol De America who were unable to hold on for a draw.
Sportivo Luqueno continued their late season surge against Cerro Porteno courtesy of goals from Marcelo Ferreira and Delris Alegre as they recorded their third successive win.
On Monday, league leaders Nacional Asuncion continued their brilliant season recording their 15th win from 18 matches with a 3 – 1 win away to General Diaz.
Midfielder Marcos Melgarejo scored his seventh goal for the season leaving the league leaders 14 points clear of the chasing pack, unable to be caught at the top of the table.
Elsewhere, Deportivo Capiata notched their seventh win of the season winning 2 – 1 over Cerro Porteno PF with Oscar Ruiz scoring a dramatic 85th minute winner.